ABSTRACT
Our main objective is to test our hypothesis that expression of viral ion channels encoded by SARS-CoV-2 genes in the heart increases the risk of sudden cardiac death and cardiac damage in COVID-19 patients with pre-existing cardiovascular disease, especially with hypertension, which is reported as a most frequent cardiovascular risk factor in COVID-19 cohorts, Moreover, recommend test the efficacy of clinically approved magnesium supplementation for preventing sudden cardiac death in COVID-19 with pre-existing hypertension. © 2022 American Institute of Physics Inc.. All rights reserved.
ABSTRACT
Background: The plant-derived bioflavonoid amentoflavone has many important biological activities, among them remarkable antiviral effects, even against severe acute respiratory syndrome Coronavirus (SARS-CoV). It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) with an IC50 value of 8.3 M. (TMPRSS-2 activity is now thought to be the only factor necessary for cell entry and viral pathogenesis). In comparison, 3CLPRO is needed for COVID-19 replication and maturation during its life cycle. Aim: This study aims to perform an in silico study on amentoflavone activity against structural and non-structural severe acute respiratory syndrome coronavirus (SARS-CoV)-2 3-chymotrypsin-like protease (3CLPRO) and human transmembrane protease serine 2 (TMPRSS-2) proteins. Materials and Methods: Molecular docking studies were carried out using compounds against 3CLPRO and TMPRSS-2 proteins through the Swiss model, Uniport, PROCHECK, Swiss PDB viewer, PyMol, PyRx, and Desmond (Schrodinger package) computerized software.